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Home - Products - Metabolic Enzyme/Protease - Phospholipase - VU 0364739 hydrochloride

VU 0364739 hydrochloride

CAS No. 1244640-48-9

VU 0364739 hydrochloride( —— )

Catalog No. M33946 CAS No. 1244640-48-9

VU 0364739 hydrochloride (VU 0364739 HCl) is a selective and potent inhibitor of phospholipase D2 (PLD2) with IC50s of 20 and 1500 nM for PLD2 and PLD1, respectively.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    VU 0364739 hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    VU 0364739 hydrochloride (VU 0364739 HCl) is a selective and potent inhibitor of phospholipase D2 (PLD2) with IC50s of 20 and 1500 nM for PLD2 and PLD1, respectively.
  • Description
    VU 0364739 hydrochloride is a highly selective phospholipase D2 (PLD2) inhibitor with IC50s of 20 and 1500 nM for PLD2 and PLD1, respectively. VU 0364739 hydrochloride induces apoptosis and it can be used for cancer research.
  • In Vitro
    Cell Proliferation Assay Cell Line:MDA-MB-231 cell line Concentration:10 μM Incubation Time:24 hours Result:Inhibited cell proliferation of MDA-MB-231 cells.Apoptosis Analysis Cell Line:MDA-MB-231 cell line Concentration:1, 10 and 100 μM Incubation Time:48 hours Result:Induced cell apoptosis at a dose of 10 μM under serum-free condition or 10% FBS containg condition.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Metabolic Enzyme/Protease
  • Target
    Phospholipase
  • Recptor
    Phospholipase | Apoptosis
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1244640-48-9
  • Formula Weight
    482.98
  • Molecular Formula
    C26H28ClFN4O2
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    Cl.O=C(NCCN1CCC2(C(=O)NCN2C=3C=CC=C(F)C3)CC1)C=4C=CC=5C=CC=CC5C4
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Lavieri RR, et al. Design, synthesis, and biological evaluation of halogenated N-(2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)ethyl)benzamides: discovery of an isoform-selective small molecule phospholipase D2 inhibitor. J Med Chem. 2010 Sep 23;53(18):6706-19.?
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